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Pharmacotherapeutic group: Peripheral vasodilator.
Pharmacology: Leukocyte properties of hemorrheologic importance have been modified in animal and in vitro human studies. Pentoxifylline has been shown to increase leukocyte deformability and to inhibit neutrophil adhesion and activation.
Pharmacokinetics: The half life of absorption of Pentoxifylline 400 is 4-6 hours. Pentoxifylline is extensively metabolized, mainly in the liver. Sixty percent of a single dose of Pentoxifylline 400 is eliminated via the kidney over 24 hours.
